General Cell Lines and Cell Cultures
ATCC Saccharopolyspora erythraea; M5-12259; genomic DNA
Genomic DNA isolated from Saccharopolyspora erythraea strain M5-12259. This bacterial strain is also available as ATCC Catalog No. 11635™.
ACROBiosystems HEK293/Cynomolgus Glypican-3 (GPC3) Stable Cell Line
Glypican-3 (GPC3) is also known as Intestinal protein OCI-5, GTR2-2, MXR7, which belongs to the glypican family. Glypican 3 / GPC-3 is highly expressed in lung, liver and kidney. Glypican-3 inhibits the dipeptidyl peptidase activity of DPP4. Glypican-3 may be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs, and also may play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function.
Eurofins Discoverx ChemiScreen D1 Dopamine Receptor Stable Cell Line, 2 vials. (HTS102C)
The ChemiScreen D1 Dopamine Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. dopamine) based activation of DRD1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses DRD1 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of DRD1, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx Ready-to-Assay α2A Adrenergic Receptor Frozen Cells, 2 Vials of Cells. (HTS096RTA)
The Ready-to-Assay α2A Adrenergic Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. epinephrine and norepinephrine) based activation of ADRA2A GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses ADRA2A alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of ADRA2A, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Eurofins Discoverx ChemiScreen C3aR Anaphylotoxin Receptor Stable Cell Line, 2 vials. (HTS016C)
The ChemiScreen C3aR Anaphylotoxin Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. C3a) based activation of C3AR1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses C3AR1 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of C3AR1, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
ATCC Staphylococcus aureus; subsp. aureus; genomic DNA
Genomic DNA isolated from Staphylococcus aureus subsp. aureus strain Wood 46. This bacterial strain is also available as ATCC® 10832™.
Eurofins Discoverx Ready-to-Assay CaS Calcium Sensor Receptor Frozen Cells, 2 Vials of Cells. (HTS137RTA)
The Ready-to-Assay CaS Calcium Sensor Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses CXCR7 based activation of CASR GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CASR alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of CASR, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Eurofins Discoverx Ready-to-Assay V1B Vasopressin Receptor Frozen Cells, 2 Vials of Cells. (HTS136RTA)
The Ready-to-Assay V1B Vasopressin Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. vasopressin) based activation of AVPR1B GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses AVPR1B alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of AVPR1B, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Eurofins Discoverx ChemiScreen mGlu2 Metabotropic Glutamate Receptor Stable Cell Line, 2 vials. (HTS146C)
The ChemiScreen mGlu2 Metabotropic Glutamate Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. glutamate) based activation of GRM2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses GRM2 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of GRM2, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx ChemiScreen PAC1-long Receptor Stable Cell Line, 2 vials. (HTS114C)
The ChemiScreen PAC1-long Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. PACAP) based activation of ADCYAP1R1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses ADCYAP1R1 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of ADCYAP1R1, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx ChemiScreen CRF2 Receptor Stable Cell Line, 2 vials. (HTS024C)
The ChemiScreen CRF2 Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CRH, sauvagine) based activation of CRHR2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CRHR2 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of CRHR2, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
ATCC Influenza A virus (H3N2); A/Hong Kong/8/68; Cell culture adapted
Influenza A virus (H3N2) strain A/Hong Kong/8/68 is propagated in MDCK (NBL-2) cells (ATCC CCL-34). This strain was isolated from a patient in Hong Kong in 1968 and was deposited by the Centers of Disease Control and Prevention. It has applications in respiratory disease and influenza research.
ATCC Salmonella enterica; subsp. diarizonae
Type strain CDC. Formerly Salmonella choleraesuis subsp. diarizonae. Control strain for detection of Salmonella.
ATCC Streptococcus mutans
Streptococcus mutans strain LRA 28 02 81 has applications in water testing and as a quality control strain for API products.